Abstract #3057

Investigation of the methionine uptake of glioma cells through deuterium magnetic resonance spectroscopy

Junyi Duan^1,2, Qian Wan¹, Ganghan Yang^1,2, Hao Peng¹, Xin Liu¹, Hairong Zheng¹, Ye Li¹, and Chao Zou¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²College of Engineering, Southern University of Science and Technology, Shenzhen, China

Synopsis

Keywords: Deuterium, Deuterium

Motivation: Glioma tumor cells have abnormally higher uptake of methionine, compared to normal brain tissues.

Goal(s): To characterize the methionine preference of glioma cells through deuterium magnetic resonance spectroscopy.

Approach: Deuterium magnetic resonance spectroscopy in glioma C6 and CTX-TNA2 glial cells incubated by [1-²H₃]-methionine

Results: Abnormal uptake of deuterated methionine in glioma cells was revealed by using magnetic resonance deuterium spectroscopy, compared to normal cells

Impact: Deuterium magnetic resonance imaging with deuterium labeled methionine may have the potential in accurate diagnosis and treatment assessment of glioma.

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