Keywords: Hyperpolarized MR (Non-Gas), Brain
Motivation: Photo-induced non-persistent radicals for dissolution Dynamic Nuclear Polarization (dDNP) reduce the delay between the preparation and injection of hyperpolarized (HP) substrates by avoiding the need for filtering potentially toxic radicals.
Goal(s): Our goal was the in vivo implementation of probes hyperpolarized with endogenous non-persistent polarizing agents.
Approach: Brain metabolism of HP glucose was monitored in a group of 12h-fasted male mice.
Results: The lactate-to-glucose ratio (LGR) was found similar to previously reported values, with a trend of higher LGR when glucose was hyperpolarized with alpha-ketoglutarate (aKG) than Trityl radicals.
Impact: Our investigation demonstrates the successful in-vivo application of radical-free HP glucose, revealing metabolic responses comparable to those achieved with stable persistent radicals and indicating the potential benefits of hyperpolarizing glucose with aKG radicals.
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