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Abstract #3071

Task Activation of Human Occipital Lobe Results in Hyperpolarized 13C-Lactate Signal Increase

Biranavan Uthayakumar1,2, Nicole I.C. Cappelletto1,2, Nadia D Bragagnolo2, Hany Soliman3, Albert P Chen4, Nathan Ma5, Fred Tam2, William J Perks5, Ruby Endre2, Simon J Graham1,2, Kayvan R Keshari6, and Charles H Cunningham1,2
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4GE Healthcare, Toronto, ON, Canada, 5Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 6Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York City, NY, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Non-Gas)

Motivation: Increases in lactate production are believed to occur in occipital lobe regions in response to visual stimuli.

Goal(s): In this study, whole-brain hyperpolarized-13C MRI was used to investigate how a visual stimulus affects occipital lobe 13C-lactate signal in healthy human volunteers.

Approach: A set of two hyperpolarized-13C MRI scans were done. Participants (n = 6) viewed a flashing checkerboard stimulus during one of the 13C scans, and had their eyes closed for the second 13C scan.

Results: Increased 13C-lactate signal was observed in the visual stimulus scans when compared to the eyes-closed scans in occipital lobe regions relative to non-occipital lobe regions.

Impact: We have shown that hyperpolarized-13C MRI is capable of measuring differences in 13C-lactate signal in response to a visual stimuli. These findings support the idea of increases in lactate production in response to stimulus. Future studies will explore other stimuli.

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Abstract

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