Abstract #3075

Imaging Tumor Metabolism in Patients with Head & Neck Squamous Cell Carcinoma

James A Bankson^1,2, Christopher M Walker^1,2, Dawid Schellingerhout³, Yunyun Chen⁴, Brandy Reed⁵, Keith A Michel^1,6, Stephanie Carlon⁵, Michelle Underwood⁵, Stacy Hash⁵, Jerell Jones⁵, Jose A Gonzalez⁵, Sandra Schuster⁵, Ehab Hanna⁴, William Morrison⁷, Luana Sousa⁸, Moin Chariwala⁹, Andrew Day⁹, C David Fuller^2,7, Vlad C Sandulache¹⁰, and Stephen Y Lai^2,4,7

¹Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States, ³Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁴Department of Head & Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁵Clinical Research Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁶Imaging Physics Residency Program, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁷Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁸Department of Thoracic-Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁹Center for Advanced Biomedical Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ¹⁰Bobby R. Alford Department of Otolaryngology - Head and Neck Surgery, Baylor College of Medicine, Houston, TX, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Hyperpolarized MR (Gas), pyruvate, metabolism, head and neck, cancer

Motivation: Changes in metabolic imaging biomarkers offer tremendous potential for assessing response and optimizing treatment for patients with head and neck squamous cell carcinoma (HNSCC).

Goal(s): To assess the translational viability of metabolic MRI with hyperpolarized (HP) pyruvate in patients with HNSCC.

Approach: Patients with HNSCC are recruited into a prospective imaging study and scanned with HP [1-13C]-pyruvate in a test-retest paradigm before start of therapy.

Results: Preliminary data indicates that reproducibility of semi-quantitative measures of tumor metabolism are high, with correlation between test-retest measurements >80% in all voxels that exceed a minimum SNR threshold and correlation >96% in regions identified as tumor.

Impact: These results demonstrate that metabolic MRI with hyperpolarized [1-13C]-pyruvate generates sufficient SNR and spatiotemporal resolution to permit reproducible measurement of tumor metabolism in patients with HNSCC.

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