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Abstract #3136

High-resolution fMRI mapping of ocular dominance columns at laminar level in cat visual cortex

Wei Zhu1, Xiao-Hong Zhu1, Yi Zhang1, and Wei Chen1
1University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (task based), ocular dominance column

Motivation: Most fMRI column studies don’t consider the potentially different laminar responses along the cortical depth.

Goal(s): In this work, we demonstrate the feasibility of mapping ocular dominance columns (ODCs) at multiple cortical depths in the cat visual cortex using CBV-weighted fMRI.

Approach: To enable monocular input to either eye of a cat, we customized a cat goggle that can avoid light leakage and switch eyes easily.

Results: By employing mesoscopic fMRI at ultrahigh magnetic field (9.4 Tesla), we observed relatively irregular ODC stripes in the cat visual cortex with a large width and length variation, extending across the cortex with varying response strength.

Impact: The successful ODC mapping across multiple cortical depths using high-resolution fMRI in the cat brain enables investigation of layer-specific neural circuits and column mapping on the effect of combined stimulus dimensions at both the thalamocortical and intracortical level.

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Keywords

cortex