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Abstract #3157

Changes in Brain Network Connectivity in Obese Patients Following Weight Loss Surgery Based on Independent Component Analysis

Junhong Duan1, Yunjie Liao1, Peng Wu2, and Pengfei Rong1
1Departments of Radiology, The Third Xiangya Hospital of Central South University, Changsha, China, 2Philips Healthcare, Shanghai, China

Synopsis

Keywords: Functional Connectivity, fMRI (resting state), Obesity, Bariatric surgery

Motivation: Bariatric surgery can rapidly alter obese status, but its effects on resting state functional connectivity (rsFC) in obesity remain unclear.

Goal(s): We examined the effects of bariatric surgery on rsFC between brain networks in obese patients using independent component analysis.

Approach: Thirty obese patients underwent resting state fMRI scans before and after bariatric surgery. We used independent component analysis to analyze surgery-related rsFC changes.

Results: Bariatric surgery improved rsFC of hVN-lFPN, hVN-SMN, AUN-pDMN, AUN-DAN, pVN-aDMN, pVN-SMN, pDMN-SN, aDMN-DAN, and SMN-DAN in obese patients. These results indicate that bariatric surgery induces functional reorganization of brain networks in obesity.

Impact: Bariatric surgery can rapidly alter obese status. Our study investigates the rsFC before and after bariatric surgery, results show that bariatric surgery induces functional reorganization of brain networks in obesity.

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