Abstract #3171

Vessel-specific quantification of cerebral venous oxygenation with velocity encoding preparation and rapid acquisition

Zixuan Lin¹, Dengrong Jiang², Yi Zhang¹, Yi-Cheng Hsu³, Hanzhang Lu², and Dan Wu¹

¹Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, ²Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ³MR Collaboration, Siemens Healthineers Ltd., Shanghai, China

Synopsis

Keywords: Oxygenation, Oxygenation

Motivation: Non-invasive measurement of cerebral venous oxygenation (Y_v) is of critical importance in numerous brain diseases.

Goal(s): The present work proposed a fast method to quantify regional Y_v map for both large and small veins, named T₂-Relaxation-Under-Velocity-Encoding-and-Rapid Acquisition (TRU-VERA).

Approach: It isolates blood spins from static tissue with velocity-encoding preparation, modulates the T₂ weighting of venous signal with T₂-preparation and utilizes a bSSFP readout to achieve fast acquisition with high resolution.

Results: Venous T₂ measured with TRU-VERA was highly correlated with T₂ from TRUST and showed an excellent test-retest reproducibility with a CoV of 1.2% for large veins and 3.6% for small veins.

Impact: The proposed TRU-VERA sequence is a promising method to for non-contrast and fast assessment of vessel-specific oxygenation, thus regional cerebral oxygen metabolism, in a number of diseases.

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