Keywords: Molecular Imaging, Molecular Imaging, anti-thrombus
Motivation: After percutaneous coronary intervention, systemic dual antiplatelet therapy prevents thrombosis which may increase the bleeding risk, especially in populations at high risk of bleeding.
Goal(s): The aim of this study was to develop PLGA-Fe3O4-Ticagrelor microspheres (PFTm), for local infusing to injured artery wall for preventing thrombosis.
Approach: Firstly, the abdominal aorta of rabbits was injured by balloon, and PLGA-Fe3O4-Ticagrelor microspheres were infuded into the injured artery, and T2WI imaging was performed.
Results: PFTm was successfully developed, which can effectively prevent thrombosis.
Impact: This study provides a new concept of local infusion for prevention of thrombosis after PCI.
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