Abstract #3194

The Successful Use of Unenriched Xenon in Dissolved Gas MRI: A Case Report

Micah Byrne Wolfsohn¹, Natalia Anya¹, Guilhem Collier², Stephen Dashnaw¹, Ryan Munro², Graham Norquay², Martin Prince³, Oliver Rodgers², Rolf Schulte⁴, Wei Shen⁵, Jim Wild², Xuzhe Zhang⁵, Emlyn Willard Hughes⁶, and Robert Graham Barr¹

¹Division of General Medicine, Columbia University Medical Center, New York, NY, United States, ²POLARIS, Imaging Section, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom, ³Weill Cornell Medicine, New York, NY, United States, ⁴GE Healthcare, Munich, Germany, ⁵Department of Biomedical Engineering, Columbia University, New York, NY, United States, ⁶Department of Physics, Columbia University, New York, NY, United States

Synopsis

Keywords: Hyperpolarized MR (Gas), COVID-19, Xenon, Blood

Motivation: We sought to demonstrate the safety and efficacy of a hyperpolarized gas MRI protocol for assessing the pulmonary physiology of long-COVID.

Goal(s): Our goal was to gather preliminary dissolved phase images utilizing unenriched xenon.

Approach: Volumes of 300mL and 500mL of unenriched xenon were hyperpolarized using a 180W diode laser at 795nm and administered to two healthy subjects. Scans were obtained using a 3T SIGNATM Premier scanner and a 129Xe Quadrature T/R lung coil. Images were masked using signal-to-noise thresholding on tissue/plasma signal.

Results: We found strong red blood cell and tissue/plasma xenon signal in both subjects utilizing 300mL of unenriched xenon.

Impact: At present time, successful dissolved xenon imaging has only been described with the use of enriched xenon-129. Our findings suggest that less expensive and more widely available unenriched xenon may be used in dissolved gas MRI.

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