Keywords: Hyperpolarized MR (Gas), Hyperpolarized MR (Gas)
Motivation: Chemical shift saturation recovery (CSSR) MR spectroscopy using hyperpolarized xenon-129 (HXe) is sensitive to abnormal lung function but lacks regionality.
Goal(s): Add regional information to CSSR MR spectroscopy with variable echo time (TE) chemical shift imaging (CSI).
Approach: Comparison of CSI-CSSR to global CSSR measurements in the lungs of a healthy and an irradiated rat.
Results: CSI-CSSR yields results comparable to whole-lung CSSR spectroscopy but with added regionality.
Impact: CSI-CSSR allows the regional quantification of apparent alveolar septal wall thickness, T2*, and resonance frequency shifts. This approach greatly enhances the sensitivity for the detection of abnormal xenon gas-exchange processes in heterogeneous lung disease.
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