Keywords: Contrast Agents, Contrast Agent, Regional Homogeneity, Functional Connectivity
Motivation: Contrast agents are widely used to increase the contrast difference between normal and abnormal tissues. Existing literature primarily focuses on the structural and perfusion effects of CAs, leaving a knowledge gap regarding their potential functional repercussions.
Goal(s): We aimed to explore the potential impact of CA administration on brain function.
Approach: We applied a combination of regional homogeneity, ROI-to-ROI, and seed-to-voxel FC analyses to rs-fMRI data from five participants before and after CA injection.
Results: Our ReHo analysis showed no significant changes of local connectivity pattern, while ROI-to-ROI and seed-to-voxel FC analyses did yield significant FC changes at network level after CA administration.
Impact: Even though the small sample size, our findings may raise an intriguing possibility that CA may indeed have the potential to influence brain function, particularly when examined at a network level.
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