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Abstract #3217

Noninvasive Visualization of Molecular Signatures of Liver Fibrosis Progression by Collagen Targeted Protein MRI Contrast Agent

Zongxiang Gui1, Dongjun Li1, Jingjuan Qiao1, Sophia Bamishaye1, and Jenny Yang2
1Georgia State University, Atlanta, GA, United States, 2Chemistry, Georgia State University, Atlanta, GA, United States

Synopsis

Keywords: Contrast Agents, Liver, chronic diseases, fibrosis, precision MRI

Motivation: Hepatic fibrosis can develop in patients with any type of chronic liver disease which increase the risk of death for an estimated 1–2% of the world’s population.

Goal(s): Our goal is to develop novel MRI contrast agents for liver diseases which enable us to detect the liver diseases at early stages.

Approach: We developed the novel MRI contrast agent for precision MRI. We achieved the molecular imaging on different animal models with liver diseases.

Results: Our results shows that our protein based MRI contrast agent can target the small lesions and fibrotic areas in the liver.

Impact: The Protein based contrast agent with specific targeting capabilities is able to stage the liver diseases accurately.

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Keywords