Keywords: Epilepsy, Epilepsy, fMRI
Motivation: There has been controversy regarding the pathophysiological basis of MRI-negative temporal lobe epilepsy (TLE-N) and its similarities and differences relative to TLE with hippocampal sclerosis (TLE-HS).
Goal(s): Static and dynamic abnormalities of spontaneous brain activity (SBA) in TLE-HS and TLE-N were examined.
Approach: Six static SBA indicators and corresponding temporal dynamic indicators were calculated using a sliding window approach, then compared.
Results: Patterns of change in SBA abnormalities were generally similar between TLE-HS and TLE-N groups; they were more pronounced in the TLE-HS group. VMHC in the hippocampus showed promise for differential diagnosis. Many indicators were correlated with cognition.
Impact: The use of static and dynamic metrics can convey a more detailed and reliable description of abnormal neuronal activity, facilitating exploration of epileptic activity and cognitive impairment mechanism in MRI-negative temporal lobe epilepsy (TLE) and TLE with hippocampal sclerosis.
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