Abstract #3219

The relationship of glutamate to glutamine and metabolic profiling in focal epilepsy using 7T CRT-FID-MRSI

Stefanie Chambers^1,2, Haniye Shayeste^1,2, Philipp Lazen^1,2, Matthias Tomschik¹, Jonathan Wais¹, Lukas Hingerl², Bernhard Strasser², Tatjana Traub-Weidinger³, Christoph Baumgartner⁴, Johannes Koren⁴, Katharina Moser⁵, Florian Mayer⁵, Martha Feucht⁵, Christian Dorfer¹, Ekatarina Pataraia⁶, Lukas Haider⁷, Gregor Kasprian⁷, Wolfgang Bogner^2,8, Siegfried Trattnig^2,8, Karl Rössler¹, and Gilbert Hangel^1,2

¹Department for Neurosurgery, Medical University of Vienna, Vienna, Austria, ²Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁴Department for Neurology, Medical Hospital Hietzing, Vienna, Austria, ⁵Center of rare and complex epilepsies, member of ERN EpiCARE, Department of Paediatrics, Medical University of Vienna, Vienna, Austria, ⁶Department for Neurology, Medical University of Vienna, Vienna, Austria, ⁷Division of Neuroradiology and Musculoskeletal Radiology, Medical University of Vienna, Vienna, Austria, ⁸Christian Doppler Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria

Synopsis

Keywords: Spectroscopy, High-Field MRI

Motivation: We want to explore the potential benefits that high-field MRSI can provide added value by allowing for higher spectral resolution of metabolites.

Goal(s): Our goal was to test the robustness of 7T-CRT-FID-MRSI in the characterization of epilepsy, in particular with respect to glutamate and glutamine.

Approach: We measured 42 patients with focal epilepsy using 7T-CRT-FID-MRSI. The obtained metabolites were normalized to ratios of NAA and tCr and concentration estimates of glutamate and glutamine were related to seizure frequency.

Results: We could demonstrate that high-field MRSI shows high sensitivity in identifying epileptic zones as well as a correlation of glutamate/glutamine ratios to seizure frequency.

Impact: 7T-CRT-FID MRSI shows high potential for identifying metabolic alterations in epilepsy. Additionally, due to higher spectral resolution, we could demonstrate a correlation of seizure frequency to the glutamate/glutamine ratio, potentially aiding in quantification of seizure burden in clinical practice.

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