Abstract #3220

Mapping Cortical Fiber Orientations in Human Focal Cortical Dysplasias Using High-Resolution Diffusion MRI

Erpeng Dai¹, Qiyuan Tian², Congyu Liao¹, Babak Razavi³, Josef Parvizi^3,4, Vivek P Buch⁴, Kawin Setsompop^1,5, Michael Zeineh¹, and Jennifer A McNab¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States, ⁴Departments of Neurosurgery, Stanford University School of Medicine, Stanford, CA, United States, ⁵Department of Electrical Engineering, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Epilepsy, Diffusion Tensor Imaging

Motivation: Detecting focal cortical dysplasia (FCD) is critical for effective neurosurgical intervention but remains technically challenging. Recent MRI technical advancements may provide new opportunities for FCD detection.

Goal(s): To determine the potential of high-resolution DTI to map cortical fiber orientation changes in FCD.

Approach: High-resolution (1 mm isotropic) DTI data were acquired on six epilepsy patients with suspected FCD. A surface-based analysis workflow was built to assess the principal fiber orientations against the cortical surface. Results in FCD were compared to the contralateral homologous region.

Results: All patients show differences in cortical fiber orientations between FCD and the contralateral presumed normal cortex.

Impact: Our study documents that high-resolution diffusion MRI can detect cortical fiber orientation changes in human FCD in vivo, which can be a novel surrogate maker for FCD detection.

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