Keywords: Data Acquisition, Quantitative Imaging, T1rho, Reproducibility, TSLs Sampling, Magnetization Preparation
Motivation: Reproducibility of T1rho measurements is crucial for longitudinal studies, as highly reproducible measurements are needed to detect treatment-induced changes in tissue properties.
Goal(s): To evaluate two novel sampling schemes of spin-locking times (TSLs) to improve the reproducibility of T1rho quantification in inhomogeneous fields (B1/B0) compared to previously reported TSL-sampling schemes.
Approach: T1rho sequences with three different T1rho preparation modules and four TSL-sampling schemes were used for repeated scans of phantom and volunteers to evaluate reproducibility in each case.
Results: The proposed TSL-sampling schemes produced significantly better reproducibility (i.e., lower coefficient of variation) than the previously reported TSL-sampling schemes.
Impact: The proposed novel TSL-sampling schemes may enable T1rho relaxation parameter as a robust biomarker of imaging tissues with a slow-motional process despite B1/B0 inhomogeneities.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords