Keywords: Pulse Sequence Design, Pulse Sequence Design
Motivation: The selection of cerebrospinal fluid (CSF) as a zero-reference can yield significant and interpretable susceptibility measurements in quantitative susceptibility mapping (QSM).
Goal(s): Our goal is to develop a 3D dual-pathway sequence capable of achieving acquisition of multi-contrast images with a reduced scan time and improving image quality. These images will be used in selecting the zero reference in QSM.
Approach: We implement a 3D double-echo steady-state echo-planar imaging (DESS-EPI) sequence with fly-back gradients, designed to generate multi-contrast images while eliminating Nyquist artifact.
Results: Our preliminary findings indicate the feasibility of utilizing multi-echo images in QSM and global CSF segmentation.
Impact: The use of global CSF as a reference in QSM can enhance susceptibility measurements. The development of our modified 3D DESS-EPI sequence improves image quality, reduces scan time, and shows promise for global CSF segmentation in QSM.
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