Abstract #3319

Validation of Resting State Functional Connectivity of S2 in Squirrel Monkey Brain: Comparisons with Optogenetic and Tactile fMRI

Zhangyan Yang^1,2, Pai-Feng Yang^1,3, Feng Wang^1,3, Jamie L Reed^1,3, Li Min Chen^1,3, and John C. Gore^1,2,3,4,5

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ²Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ⁴Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States, ⁵Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: Functional Connectivity, Brain

Motivation: To validate the derivation of functional networks from resting state and confirm the contribution of specific neuron types to BOLD responses.

Goal(s): Our aim is to compare resting state BOLD-derived functional networks with those from neuron-type selective optogenetic and natural tactile stimulationin the non-human primate brain.

Approach: We compared the BOLD signals in the brains of squirrel monkeys under three conditions: in response to blue light optogenetic stimulation, vibrotactile stimulation of fingers, and in a resting state.

Results: It shows the neural specificity of the optogenetic fMRI approach and its potential to enhance the understanding of brain circuits and connectivity within S2.

Impact: This study's validation of functional networks from resting-state BOLD acquisitions and the confirmation of optogenetic fMRI's neural selectivity helps with the understanding brain function. These results encourage further investigations for deeper insights into neurological conditions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.