Abstract #3322
AwakeRodent, the multi-center, multi-species, multi-modality study!
Marie E Galteau1, Binshi Bo2, Hui Li3, Mengchao Pei2, Mengyang Xu4,5,6, Zhifeng Liang2, Qikai Qin4,6, Garth J Thompson4, Alejandro Trouvé-Carpena7, Alejandro Sempere-Ferràndez7, Santiago Canals7,8, Luis Tuset-Sanchis7, A. Elizabeth de Guzman9, Andrew Hayward9, Alessandro Gozzi9, Daniel Gutierrez-Barragan9, Daphne M.P. Naessens10, Bram F. Coolen10, Lindy K. Alles10, Gustav J. Strijkers10, Liesbeth Reneman10, Lenka Dvořáková11, Petteri Stenroos11, Jaakko Paasonen11, Olli Gröhn11, Ruoming Wang12, Qian Chen12, Xiangnan Tian12, Mengchao Pei13, Zhifeng Liang13, Zhiwei Ma12, Andrea Moreno8, Roël M. Vrooman1, and Joanes Grandjean1
1Donders Institute for Brain, Behaviour, and Cognition, Radboud University, Nijmegen, Netherlands, 2CAS Center for Excellence in Brain Sciences and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China, 3iHuman Institute, ShanghaiTech University, Shanghai, China, 4ShanghaiTech University, Shanghai, China, 5Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China, 6University of Chinese Academy of Sciences, Beijing, China, 7Instituto de Neurociencias, CSIC-UMH, San Juan de Alicante, Spain, 8Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark, 9Center for Neuroscience and Cognitive systems, Istituto Italiano di Tecnologia, Rovereto, Italy, 10Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, 11A.I.V. Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 12School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, 13Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China
Synopsis
Keywords: fMRI Acquisition, Brain, awake imaging, rodents, multi-center
Motivation: To bring awareness on the heterogeneity in awake rodent functional imaging. We aim to identify protocol differences that optimize awake functional connectivity, reproducibility and collaboration.
Goal(s): To aggregate awake rodent functional datasets, establish population parameters, provide evidence-based recommendations, compare functional Magnetic Resonance Imaging and functional Ultrasound, foster collaborations.
Approach: We collect datasets from mice and rats, preprocess and run a seed-based analysis at the individual-level using RABIES. Group-level analysis is performed in Python, resulting in functional connectivity specificity maps.
Results: We have gathered 5 mice-datasets and 4 rat-datasets totaling 122 scans with great variability in rodent characteristics, imaging methods, and experimental designs.
Impact: Findings will empower researchers to refine awake rodent functional imaging, enhancing investigations into cognitive and behavioral processes, without the anesthesia confounds. This approach closely parallels human brain imaging, enhancing translational relevance and providing an accurate representation of conscious brain function.
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