Keywords: Task/Intervention Based fMRI, fMRI (task based), functional connectivity, acute post-surgical pain, sex difference, mechanosensation, dimensionality reduction, principal component analysis
Motivation: Acute postsurgical pain remains difficult to treat and may result in complications including chronic pain and increased use of opioids if insufficiently controlled.
Goal(s): A better understanding of the mechanisms inducing and maintaining these pain states is critical in both sexes.
Approach: Longitudinal task fMRI was performed with two different mechanical stimulations in male and female mice following acute incision pain (INC) compared to sham-treated animals.
Results: Our mixed-method analysis approach identifies INC-regulated brain regions and highlights divergent mechanical pain processing in mice of both sexes.
Impact: Our mixed-method analysis approach integrating the general linear model analysis combined with principal component analysis and analysis of functional connectivity provides deep insights into CNS plasticity during incision-induced pain and provides detailed information on relevant brain regions and interaction patterns.
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