Abstract #3327

Zero-echo time MB-SWIFT MRI responses to visual stimuli in a mouse model of demyelination and remyelination

Lenka Dvořáková¹, Raimo A. Salo¹, Petteri Stenroos¹, Jaakko Paasonen¹, Tamara Zehnder², Thomas Mueggler², Basil Künnecke², and Olli Gröhn¹

¹A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ²Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (task based), Zero echo time, demyelination, remyelination

Motivation: The changes in responses to sensory stimuli during demyelination and remyelination could help quantify neuro-functional deficits in neurodegenerative disorders.

Goal(s): The goal of this study was to explore the capability of fMRI to detect changes in the functional response during both demyelination and remyelination.

Approach: A genetic mouse model of widespread demyelination and remyelination was imaged with MB-SWIFT fMRI during visual stimulation.

Results: We observed alterations in activation maps and fMRI responses to visual stimuli during demyelination. The function was restored during the remyelination phase.

Impact: We show that zero echo time MB-SWIFT fMRI protocol with visual stimulation can detect myelination-associated differences in neuro-functional responses in mice and thus lends itself as a potential translational biomarker for disease and treatment monitoring in drug development.

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