Keywords: Task/Intervention Based fMRI, fMRI (task based), Excitation and Inhibition balance, Mouse fMRI, Autism
Motivation: The hyper- or hyporeactivity to sensory input is a common diagnostic criterion in autism, potentially influencing BOLD signals.
Goal(s): Our study was centered on unraveling the underlying mechanisms governing the positive and negative BOLD responses to low and high sensory stimulus frequencies. A ratio of BOLD responses of high frequency to low frequency may reflect E:I balance.
Approach: Our study delved into BOLD responses during varied sensory stimulation frequencies
Results: We observed increased neural activity and BOLD responses at lower frequencies, contrasting with suppressed cortical activity and subsequent negative BOLD responses at higher frequencies.
Impact: A ratio of BOLD responses of high frequency to low frequency may reflect E:I balance, necessary for the clinical utility of BOLD fMRI to hyper- or hypo-reactivity responses to sensory inputs in autism
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords