Abstract #3336

PSMA PET/CT and mpMRI discrepancies in prostate cancer detection with whole-mount histopathology gold standard

Ida Sonni¹, Sahith Doddipalli¹, Madhvi Deol¹, David Ban¹, Hye Ok Kim¹, Tristan Grogan², Preeti Ahuja¹, Nashla Barroso¹, Yang Zong³, Priti Soin³, Adam B Weiner⁴, Anthony Sisk³, Jeremie Calais⁵, William Hsu¹, Johannes Czernin⁵, Robert E Reiter⁴, and Steven S Raman¹

¹Radiology, UCLA, Los Angeles, CA, United States, ²Statistics, UCLA, Los Angeles, CA, United States, ³Pathology, UCLA, Los Angeles, CA, United States, ⁴Urology, UCLA, Los Angeles, CA, United States, ⁵Molecular and Medical Pharmacology - Nuclear Medicine, UCLA, Los Angeles, CA, United States

Synopsis

Keywords: Prostate, Prostate

Motivation: In prostate cancer (PCa), multiparametric MRI (mpMRI) and PSMA-PET aid pre-surgical assessment. This study evaluates parameters linked to the agreement/disagreement of PSMA-PET and mpMRI with histopathology.

Goal(s): To evaluate the concordance between PSMA-PET, mpMRI, and histopathology in PCa lesion identification.

Approach: Patients with PSMA-PET, mpMRI, and histopathology data were analyzed. Imaging lesions were contoured independently. Sensitivity and agreement were assessed. Logistic regression models examined factors affecting concordance.

Results: Among 114 patients, PSMA-PET and mpMRI identified 170 and 138 lesions, respectively. Tumor aggressiveness and size impacted agreement. Higher SUVmax on PSMA-PET and higher ISUP grade and size on pathology were associated with concordance.

Impact: This work improves prostate cancer diagnosis by identifying key factors influencing the agreement between PSMA-PET, mpMRI, and histopathology, offering valuable insights for more precise pre-surgical assessments.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.