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Abstract #3360

High Lp(a) (Lipoprotein[a]) Is Associated with Wall Enhancement and Irregular Pulsation of Unruptured Intracranial Aneurysm

Jianjian Zhang1, Xiao Li1, Yang Song2, and Huilin Zhao1
1Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2MR Research Collaboration Team, Siemens Healthineers Ltd. Shanghai, Shanghai, China

Synopsis

Keywords: Vessel Wall, Cardiovascular

Motivation: Atherosclerotic proteins have been implicated with inflammation and remodeling of aneurysm wall. Both aneurysm wall enhancement (AWE) and irregular pulsation have been suggested as potential candidates for intracranial aneurysms (IAs) instability.

Goal(s): To explore the association between atherosclerotic proteins and AWE and irregular pulsation.

Approach: Using vessel wall MRI and four-dimensional computed tomography angiography

Results: We found higher level of serum Lp(a) (Lipoprotein[a]) was significantly associated with increased wall enhancement and irregular pulsation of IAs (both p<0.05)

Impact: This study established a link between atherosclerotic proteins and AWE and irregular pulsation, inflammation and wall remodeling.

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