Keywords: Heart Failure, Cardiovascular
Motivation: To investigate the cardioprotective effects of paeoniflorin on myocardial infarction-induced ventricular remodeling in high-altitude hypobaric hypoxia environments.
Goal(s): To evaluate the potential protective role of paeoniflorin in a rat model of myocardial infarction-induced ventricular remodeling under high-altitude hypobaric hypoxia using cardiovascular magnetic resonance strain analysis.
Approach: Rats were allocated to plain sham operation control, high-altitude sham operation control, high-altitude myocardial infarction operation, and paeoniflorin treatment groups. CMR assessed cardiac function.
Results: Paeoniflorin treatment groups demonstrated enhanced left ventricular function and regional strains compared to the myocardial infarction group. Histological analyses also showed reduced myocardial injury and fibrosis with paeoniflorin treatment.
Impact: The study's outcomes have implications for managing patients at risk of MI, especially those in high-altitude environments or exposed to hypobaric hypoxia.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords