Abstract #3390
Signal intensity and volume of carotid intraplaque hemorrhage on MRI and ipsilateral cerebrovascular events: the Plaque At RISK (PARISK) study
Kelly P.H. Nies1,2, Mueez Aizaz1,2, Dianne H.K. van Dam-Nolen3,4, Timothy C.D. Goring5, Tobien A.H.C.M.L. Schreuder6, Narender P. van Orshoven7, Alida A. Postma1,8, Daniel Bos3,9, Jeroen Hendrikse10, Paul Nederkoorn5, Rob van der Geest11, Robert J. van Oostenbrugge2,12, Werner H. Mess2,13, and M. Eline Kooi1,2
1Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 2Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands, 3Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, Netherlands, 4Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands, 5Department of Neurology, Amsterdam University Medical Center, Amsterdam, Netherlands, 6Department of Neurology, Zuyderland Medical Center, Heerlen, Netherlands, 7Department of Neurology, Zuyderland Medical Center, Sittard, Netherlands, 8School for Mental Health and Neuroscience (MHeNs), Maastricht University, Maastricht, Netherlands, 9Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands, 10Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands, 11Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 12Department of Neurology, Maastricht University Medical Centre, Maastricht, Netherlands, 13Department of Clinical Neurophysiology, Maastricht University Medical Centre, Maastricht, Netherlands
Synopsis
Keywords: Atherosclerosis, Stroke
Motivation: The presence of intraplaque hemorrhage (IPH) is a strong independent stroke predictor. Higher IPH signal intensity ratios (SIR) and volumes were found in symptomatic versus asymptomatic carotid arteries.
Goal(s): To determine if IPH SIR and volume are associated with the risk for ipsilateral ischemic neurovascular events in symptomatic patients with <70% carotid stenosis.
Approach: Cox proportional hazards and logistic regression were used to explore the association of IPH SIR and volume to ipsilateral ischemic neurovascular events in 87 IPH-positive patients.
Results: IPH SIR and IPH volume were not associated with risk for ipsilateral ischemic events during 5.1(IQR:3.1-5.6) years.
Impact: No association was found between IPH SIR or volume and the risk for ipsilateral ischemic neurovascular events or new infarcts on brain MRI. Therefore, identifying the presence of IPH is sufficient for risk stratification.
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