Abstract #3398

Myocardial Pre-contrast T1 at 3T Detects Progressive Changes in Duchenne Muscular Dystrophy

Nyasha Maforo¹, Ashley Prosper², Pierangelo Renella^2,3, Nancy Halnon⁴, Holden Wu², and Daniel Ennis⁵

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ³Cardiology, Childrens Hospital of Orange County, Orange, CA, United States, ⁴Pediatric Cardiology, University of California, Los Angeles, Los Angeles, CA, United States, ⁵Radiolgy, Stanford University, Palo Alto, CA, United States

Synopsis

Keywords: Cardiovascular, Cardiomyopathy

Motivation: Duchenne muscular dystrophy (DMD) leads to pediatric cardiomyopathy. Pre-contrast T1 in DMD identifies myocardial remodeling, but it remains unclear if T1-Mapping biomarkers can detect longitudinal changes in DMD.

Goal(s): The objective was to characterize progressive myocardial pre-contrast T1 changes in DMD at 3T.

Approach: Boys with DMD and healthy controls underwent a 3T CMR exam that included standard functional and pre-contrast T1 mapping sequences. Boys with DMD were examined at two points (18 months apart).

Results: Pre-contrast T1 was capable of detecting progressive changes in boys with DMD 18 months post baseline while functional metrics like LVEF did not.

Impact: T1 Mapping biomarkers can detect disease progression in DMD. T1 Mapping biomarkers, in combination with biomarkers of function have the potential to track patient-specific changes.

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