Abstract #3405

Novel Doppler US-gated 3D fetal whole-heart MRI with motion correction: initial validation using paired phase-contrast flow data

Tomas Woodgate^1,2, Johannes Steinweg^1,2, Rachael Franklin^1,3,4, Anthony Price^1,3,4, Thomas Roberts^1,3, Arnaud Boutillon^1,3, Alena Uus^1,3, Jana Hutter⁵, Jo Hajnal^1,3, Maria Deprez^1,3, Kuberan Pushparajah^1,2, and David Lloyd^1,2

¹Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Department of Congenital Heart Disease, Evelina Children's Hospital, London, United Kingdom, ³Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁴Guys and St Thomas' NHS Foundation Trust, London, United Kingdom, ⁵School of Biomedical Sciences, King's College London, London, United Kingdom

Synopsis

Keywords: Prenatal, Fetus

Motivation: A novel pipeline for the creation of 3D fetal whole-heart datasets has been devised by combining Doppler US-gating and slice-to-volume registration.

Goal(s): Our goal was to perform initial validation of the resultant 3D+t datasets.

Approach: We assessed for internal consistency by deriving fetal stroke volume data from two methods in six subjects. Stroke volume data were obtained through volumetric analysis of the 3D+t volume alongside assessment of paired 2D+t phase-contrast flow data.

Results: There was correlation between volumetrically derived stroke-volume data with that derived from 2D+t phase contrast flow, however the volumetric method was biased toward lower readings.

Impact: Initial validation of a novel pipeline for the creation 3D fetal whole-heart datasets shows correlation between stroke volumes derived from volumetry and phase contrast flow data. Future work will explore the bias toward lower stroke volumes obtained by volumetry.

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