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Abstract #3407

Reliability of fetal 4D flow in healthy volunteers and patients with suspected congenital cardiovascular anomalies

Erin K Englund1, Takashi Fujiwara1, Sarah Smith2, Mariana L Meyers1, Richard M Friesen3, Lorna P Browne1, and Alex J Barker1,4
1Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 2Department of Radiology, Children's Hospital Colorado, Aurora, CO, United States, 3Pediatric Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, 4Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, United States

Synopsis

Keywords: Fetal, Fetus, 4D flow

Motivation: Fetal 4D flow provides useful information related to cardiovascular structure and function, but its reliability is not yet defined.

Goal(s): Here, we seek to define the accuracy, precision, internal consistency, and repeatability of fetal 4D flow.

Approach: Pregnant women in their third trimester with healthy developing fetuses (N=22) and fetuses with suspected cardiovascular anomalies (N=12) were scanned with 2D phase contrast and 4D flow sequences. Quantitative flow metrics were compared.

Results: 4D flow underestimated net flow in the great vessels relative to 2D-PC, but had reasonable precision, internal consistency, and repeatability. Fetal 4D flow can reliably measure percentage contributions from various vascular territories.

Impact: Fetal 4D flow allows for quantitative hemodynamic evaluation of the fetal cardiovascular system with good precision, internal consistency, and repeatability. Flow was underestimated relative to 2D-PC, therefore presently percent contribution from various vascular territories is the most appropriate clinical endpoint.

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Keywords