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Abstract #3408

SNAKE-fMRI: A modular fMRI simulator from the space-time domain to k-space data and back

Pierre-Antoine Comby1,2,3, Alexandre Vignaud1,2, and Philippe Ciuciu1,2,3
1CEA/Neurospin, Gif-Sur-Yvette, France, 2Université Paris-Saclay, Gif-sur-Yvette, France, 3Inria Saclay, Palaiseau, France

Synopsis

Keywords: fMRI Acquisition, Simulations

Motivation: fMRI is a powerful tool for neuroimaging, but its optimization in vivo is complicated due to limited reproducibility. Simulation setup can help, but current solutions lack flexibility, control, or efficiency.

Goal(s): Develop a versatile and efficient fMRI simulator generating realistic fMRI data under various conditions: SNR levels, acceleration factors, spatiotemporal resolutions, noise, and artifact sources.

Approach: We propose SNAKE-fMRI, a modular, open-source fMRI simulator that operates from image to k-space and vice-versa. It can generate 3D+time k-space and images, mimicking the entire fMRI acquisition process, with potential k-t accelerations.

Results: We showcase the use of SNAKE-fMRI on a non-Cartesian k-t accelerated scenario.

Impact: With SNAKE-fMRI as an open-source, versatile, and efficient fMRI simulator, researchers can generate realistic fMRI data under a controlled and fully reproducible setup, enabling new advancements in fMRI acquisition and reconstruction methods.

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Keywords