Keywords: fMRI Acquisition, fMRI (task based), line-scanning fMRI method
Motivation: Spin-echo-based line-scanning employing inner-volume excitation has been proposed for line-scan fMRI to avoid artifacts stemming from imperfect saturation RF pulses.
Goal(s): To measure non-contiguous and non-coplanar BOLD signals at multiple cerebral cortical areas.
Approach: We developed multi-line T2’- and T2-weighted Gradient-echo sampling of a spin-echo (GESSE) line-scanning fMRI method.
Results: This novel approach enables the detection of fMRI activation at different visual cortical regions, showing pure T2 and TE-dependent BOLD responses. It provides a proof-of-concept to further examine interactions of high-resolution fMRI signals at multiple cortical locations along feedforward and feedback pathways.
Impact: A non-coplanar multi-line gradient-echo sampling of spin-echo (GESSE) line-scanning method was proposed as a novel approach for distinguishing macro- and micro-vascular sensitive fMRI signals by simultaneouslyacquiring T2’- and T2-weighted BOLD fMRI signals at multiple cortical locations.
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