Abstract #3427

Comparing functional connectivity of small nucleus in brainstem with multi- and single-echo fMRI: A resting state study

Xinhui Wang¹, Qiurong Yu¹, Naying He¹, Kai Ai², Youmin Zhang¹, Peng Liu¹, Yan Li¹, Peng Wu³, and Fuhua Yan^4,5

¹Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Philips Healthcare, Xi'an, China, ³Philips Healthcare, Shanghai, China, ⁴Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁵College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

Keywords: Functional Connectivity, fMRI

Motivation: Efforts to characterize the function of DR, MR and LC in humans using functional magnetic resonance imaging (fMRI) have been hampered by their small size and location near a large source of noise.

Goal(s): The aim of this study is to compare the functional connectivity (FC) of small nucleus in brainstem with multi- (ME) and single-echo (SE) resting state fMRI.

Approach: The whole-brain FC of LC, DR and MR were generated by using ME-fMRI and SE-fMRI.

Results: Precuneus was correlated with LC in both methods. Meanwhile, both methods shown cerebellum was correlated with DR, the cingulum was correlated with MR.

Impact: It suggests that ME-fMRI may also provide significant advantages over single echo fMRI approaches when investigating the FC of small nucleus of brainstem. ME-fMRI offers substantial advantages over single echo fMRI.

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