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Abstract #3437

Assessing motion-associated tSNR of brainstem and spinal cord fMRI in a cohort with chronic hemiparetic stroke

Kimberly J. Hemmerling1, Neha A. Reddy1, Julius P. A. Dewald1, and Molly G. Bright1
1Northwestern University, Chicago, IL, United States

Synopsis

Keywords: Task/Intervention Based fMRI, Spinal Cord, brainstem

Motivation: Motor-task fMRI is a critical modality for studying post-stroke neuronal changes in the brainstem and spinal cord, but data quality is reduced in these regions.

Goal(s): We aimed to anticipate the degree of head-motion confounds before a motor-task fMRI scan and assess how this head motion affects fMRI data quality.

Approach: Six post-stroke individuals performed a hand-grasp task during a head motion-capture session, then during cortical-brainstem and spinal-cord fMRI scans.

Results: Head motion in the lab was positively correlated with head and spinal-cord motion during fMRI. Head and spinal-cord motion were correlated with decreased tSNR in the cortex, brainstem, and spinal cord.

Impact: Head motion outside of the scanner is linked with head and spinal-cord fMRI motion and tSNR. With lab-based motion capture systems, we can anticipate motion and tSNR impacts in motor-task fMRI, useful as screening in clinical populations with increased movement.

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Keywords