Keywords: Microstructure, Microstructure, diffusion, brain, exchange, gray matter, water, microstructure, simulation, spines, dendrites
Motivation: Diffusion exchange models NEXI and SMEX assumes permeative exchange between intra- and extra-neurite compartments. Here, we hypothesize fine microstructures, like spines in dendritic segments, without permeable membranes can mimic permeative exchange.
Goal(s): We aim to emphasize the significance of taking diffusion-mediated exchange into account when interpreting model-based estimates of exchange in intricate microstructures like the gray matter of the brain.
Approach: Monte-Carlo water diffusion simulations in spiny dendritic branches, also featuring undulations and beading
Results: Our results question the way we interpret dMRI exchange estimates, emphasizing the need to exercise caution when inferring these estimates solely as indicators of membrane permeability.
Impact: Diffusion exchange models assumes permeative exchange between intra- and extra-neurite compartments. We hypothesize fine microstructures without permeable membranes can mimic permeative exchange. We aim to emphasize considering the impact of intricate microstructures in gray matter when interpreting model-based exchange estimates
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords