Abstract #3465

Time-Dependent Standard Model of diffusion in human brain white matter evaluated in vivo on the high gradient performance Connectome 2.0 scanner

Kwok-Shing Chan^1,2, Yixin Ma^1,2, Hansol Lee^1,2, Santiago Coelho^3,4, Els Fieremans^3,4, Dmitry S. Novikov^3,4, Susie Huang^1,2, and Hong-Hsi Lee^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ⁴Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States

Synopsis

Keywords: Microstructure, Microstructure

Motivation: While most biophysical models in brain white matter estimate Gaussian compartment parameters, characteristic length scales of tissue microstructure can only be obtained from non-Gaussian features.

Goal(s): To introduce time dependence into the Standard Model of diffusion; to in vivo evaluate non-Gaussian signatures of diffusion in intra- and extra-neurite spaces, irrespective of neurite orientation dispersion.

Approach: We perform diffusion measurements on the Connectome 2.0 scanner in healthy volunteers at short times (13-30 ms) and estimate time-dependent diffusion parameters using GPU-accelerated fitting.

Results: Time-dependent diffusion signals up to 2^nd-order in spherical harmonics provide sensitivity potentially related to axonal beadings and packing correlation length.

Impact: We demonstrated the feasibility of mapping time-dependent diffusion in human white matter in vivo using the Connectome 2.0 scanner. This potentially provides novel biomarkers sensitive to axon beadings and packing length scales for investigation of neurological disorders.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.