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Abstract #3490

Memory impairment is associated with glymphatic dysfunction in hemodialysis patients

Hui Juan Chen1, Jie Qiu1, Yihao Guo1, Haodong Qin2, and Feng Chen1
1Hainan General Hospital, Haikou, China, 2MR Research Collaboration, Siemens Healthineers, Guangzhou, China

Synopsis

Keywords: Diffusion Analysis & Visualization, Kidney

Motivation: Glymphatic function assessed by diffusion tensor image analysis along the perivascular space (DTI-ALPS) index might be associated with cognitive function.

Goal(s): To examine the glymphatic function in patients who receive regular hemodialysis and its relationship with clinical indices.

Approach: Partial correlation analysis was applied to assess the relationship between ALPS index and clinical markers with age and sex as covariates.

Results: Left ALPS index is positively correlated with immediate recall scores after adjusting for age and gender.

Impact: Glymphatic function and hemoglobin levels are associated with memory dysfunction in hemodialysis patients, offering a potential way to improve memory function in this population.

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