Abstract #3494

MAP-MRI: a Potential Tool for Investigating Pathophysiological Mechanisms in Pediatric Basic Intermittent Exotropia

Ruijia Zhao¹, Qing-lei Shi^1,2, Yuchen Gu³, Chen Wang², Yifan Han⁴, Xianchang Zhang⁵, Xiang Wan², Ren-zhi Wang¹, and Zhaohui Liu⁶

¹School of Medicine, The Chinese University of Hong Kong, Shenzhen, Shenzhen, China, ²Shenzhen Research Institute of Big Data, Shenzhen, China, ³The Chinese University of Hong Kong, Shenzhen, Shenzhen, China, ⁴School of Computer Science and Engineering, Beihang University, Beijing, China, ⁵MR Research Collaboration, Siemens Healthineers Ltd., Beijing, China, ⁶Beijing Tongren Hospital, Capital Medical University, Beijing, China

Synopsis

Keywords: Diffusion Modeling, Diffusion/other diffusion imaging techniques, MAPMRI

Motivation: To better understand the pathophysiological progression mechanism of childhood basic-type IXT and develop an accurate approach for early diagnosis.

Goal(s): To find a valuable tool in reflecting the pathological changes of the visual center pathway in IXT children.

Approach: A voxel-wise analysis was performed for MAPMRI-derived parameters between IXT patients and health controls, and a DTI analysis was used as reference.

Results: Compared with DTI, MAPMRI-derived parameters demonstrated significant differences in more brain regions associated with visual cortex. Brain regions with microstructural changes include MOG.R, SOG.R, IOG.R, and MTG.R.

Impact: We firstly explored MAPMRI’s value in detecting abnormal pathological changes of the primary and higher visual center, and the ocular movement pathway in children with basic IXT. This discovery enhances comprehension of IXT's pathology and offers insights for early diagnosis.

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