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Abstract #3505

Improved correction of B0 inhomogeneity-induced distortions in prostate diffusion images

Christopher C Conlin1, Rebecca Rakow-Penner1, Tyler M Seibert1,2,3, and Anders M Dale1,4,5
1Department of Radiology, University of California San Diego, La Jolla, CA, United States, 2Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, United States, 3Department of Bioengineering, University of California San Diego, La Jolla, CA, United States, 4Department of Neurosciences, University of California San Diego, La Jolla, CA, United States, 5Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, United States

Synopsis

Keywords: Prostate, Diffusion/other diffusion imaging techniques, B0-inhomogeneity distortion correction

Motivation: The Jacobian intensity correction (JIC) of conventional EPI-distortion correction methods can conceal severe under-correction and even create false anatomical structure.

Goal(s): Demonstrate the shortcomings of JIC methods and present an alternative distortion-correction technique that obviates the need for a JIC.

Approach: Acquiring DWI images with opposite phase-encoding polarity at multiple b-values and normalizing prior to estimating tissue displacement eliminates the need to account for intensity scaling with the JIC. This approach, referred to as mRPG, was compared against conventional distortion correction methods.

Results: mRPG significantly improved the estimation and removal of spatial distortions compared to conventional methods.

Impact: Jacobian intensity correction (JIC) can generate misleading improvement of EPI distortion and create false structure in prostate diffusion images. Eliminating the JIC, by acquiring opposed-phase images at multiple b-values and normalizing prior to correction, results in improved EPI distortion correction.

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Abstract

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