(ISMRM 2024) A Non-Linear Gradient Insert for Prostate Diffusion Imaging
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Abstract #3507

A Non-Linear Gradient Insert for Prostate Diffusion Imaging

Nahla M H Elsaid1, Horace Z. Zhang2, Terence Nixon1, R. Todd Constable1,3, Jeffrey Weinreb1, and Gigi Galiana1,2
1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 2Biomedical Engineering, Yale University, New Haven, CT, United States, 3Neurosurgery, Yale University, New Haven, CT, United States

Synopsis

Keywords: Prostate, Cancer

Motivation: A sensitive imaging method that distinguishes benign or low-grade prostate lesions from aggressive ones is one of the greatest needs in prostate cancer.

Goal(s): To develop new prostate DWI technique using a non-linear gradient (NLG) to improve the diagnostic accuracy of prostate cancer.

Approach: Using an NLG coil, we can circumvent the challenge of high b-value requirements by having a gradient with a high amplitude within a limited field of view, which applies to prostate imaging.

Results: We demonstrate feasibility of using an NLG for prostate imaging, after validation with a polyvinylpyrrolidone (PVP) phantom and testing SE and EPI sequences with prostate ADC-mapping.

Impact: To better diagnose prostate cancer with high sensitivity, we use an NLG insert coil. Using only one DWI and one non-diffusion image we showed comparable ADC maps to those produced using gold standard multi-shell linear gradient sequences.

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Keywords

prostatecancerdiffusiongradientlinear