Keywords: Prostate, Cancer, prostate cancer, brachytherapy, radiotherapy, MR spectroscopy
Motivation: Monitoring time-dependent effects of prostate brachy- and radiotherapy.
Goal(s): Assessment of prostate metabolic activity during and three months after the completion of brachy- and/or external beam radiotherapy.
Approach: Single-voxel 1H-MRS with a surface receiver coil.
Results: It is demonstrated that the proposed 1H-MRS approach is a useful tool for monitoring metabolic changes in prostate tissues treated with brachy- and/or external beam radiotherapy. We found reduction of citrate intensity close to the noise level to be the most reliable measure for identification of metabolic atrophy and response to therapy.
Impact: Single-voxel 1H-MRS with a surface receiver coil is an effective method for monitoring the response of prostate tissues to brachy- and/or external beam radiotherapy. Good response to prostate radiotherapy might be characterized by low citrate intensity.
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