Keywords: Myocardium, Preclinical, RAFF2, Rotating frame relaxations, myocardial infarct
Motivation: Current MRI techniques are insufficiently sensitive to determine specific physiological changes in the myocardium after infarction.
Goal(s): To optimize sensitivity of RAFF2 technique to specific tissue changes of the myocardium after myocardial infarct (MI) by modulating the durations of P-packets of RAFF2 pulses.
Approach: Mice hearts are imaged ex vivo 7 days after the factitious myocardial infarction by using different durations of P-packets of the RAFF2 along with other rotating frame relaxation techniques.
Results: Duration of the RAFF2 pulse have an impact on relaxation maps and contrast of MI area compared to the remote area. Increased rotating frame relaxation times were also detected.
Impact: This study presents novel application of RAFF2 technique for quantitative ex vivo assessment of mice myocardium after infarction. This method allows to study physiological changes in the myocardium with high sensitivity.
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