Abstract #3535

Accelerated ferumoxytol-enhanced free-running acquisitions for whole-heart angiography in congenital heart disease patients.

Ludovica Romanin^1,2, Christopher W Roy¹, Jérôme Yerly^1,3, Bastien Milani¹, Milan Prsa⁴, Tobias Rutz⁵, Salim Si-mohamed^1,6,7, Estelle Tenisch¹, Davide Piccini^1,2, and Matthias Stuber^1,3

¹Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ²Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ³Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ⁴Division of Pediatric Cardiology, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁵Service of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁶University Lyon, INSA-Lyon, University Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS, Villeurbanne, France, ⁷Department of Radiology, Louis Pradel Hospital, Bron, France

Synopsis

Keywords: Vascular, Cardiovascular, Rapid MRI

Motivation: Angiography using ferumoxytol-enhanced free-running MRI can be obtained within an acquisition window of 6 minutes, which could be further reduced for faster clinical workflows.

Goal(s): To determine the lower bounds of scan time for fast free-running whole-heart MRI using a data-driven reconstruction (SIMBA).

Approach: Fifteen datasets were retrospectively undersampled and image quality metrics were determined as a function of scan time reduction.

Results: A 3-minute acquisition provides comparable image quality to that of its original 6-minute counterpart, and when applying compressed sensing we can confidently further reduce the acquisition time of 3D MR angiography with high resolution to 2 minutes.

Impact: Free-running whole-heart MRI acquisitions can be greatly sped-up by exploiting ferumoxytol contrast enhancement, in conjunction with a data-driven reconstruction, which facilitates fast whole-heart angiography in congenital heart disease patients.

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