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Abstract #3556

Motion-robust Three-dimensional Magnetic Resonance Fingerprinting (MR-3DMRF) for Quantitative Abdominal Imaging

Chenyang Liu1, Lu Wang1, Peng Cao2, Tian Li1, and Jing Cai1
1Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China, 2Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, China

Synopsis

Keywords: MR Fingerprinting, MR Fingerprinting, Motion Correction

Motivation: Current abdominal magnetic resonance fingerprinting (MRF) techniques require breath-hold acquisition to avoid motion artifacts, which is difficult for patients with breathing difficulties.

Goal(s): This study aims to develop a motion-robust three-dimensional MRF (MR-3DMRF) technique for abdominal patients and evaluate the repeatability of tissue property quantification.

Approach: MR-3DMRF incorporates a non-smooth motion modeling method and a dynamic weighting strategy to allow free-breathing MRF acquisition and motion-resolved reconstruction.

Results: Full-width half-maximum of organ boundaries in MR-3DMRF-derived tissue maps is 3.1mm±1.8mm, significantly lower than motion-blurred tissue maps (10.1mm±4.3mm). The linearity of test-retest MRF measurement for T1, T2, and PD was 0.982, 0.894, 0.925, respectively.

Impact: This study, for the first time, investigates the feasibility of free-breathing MRF acquisition and motion-resolved MRF reconstruction on abdominal patients. The MR-3DMRF-derived tissue map are highly repeatable and accurate, potentially contribute to abdominal disease diagnosis and treatment assessment.

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