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Abstract #3585

Discordant Molecular, Imaging, and Survival Manifestations between Molecular Glioblastomas and Histological Glioblastomas

Yae Won Park1, Sung Soo Ahn1, Seung-Koo Lee1, and Rajan Jain2
1Radiology, Yonsei University College of Medicine, Seoul, Korea, Republic of, 2NYU Langone, New York, NY, United States

Synopsis

Keywords: Tumors (Pre-Treatment), Brain, glioma; glioblastoma; molecular glioblastoma

Motivation: Whether molecular GBMs are equivalent to early histological GBMs are controversial.

Goal(s): To compare the clinicopathologic, imaging, surgical factors, and prognosis between molecular GBMs and histological GBMs.

Approach: Retrospective chart and imaging review was performed in 974 IDH-wildtype GBM patients (43 molecular GBMs and 931 histological GBMs) from a single institution.

Results: Molecular GBMs were significantly younger with higher rate of TERTp, higher incidence of gliomatosis cerebri and non-lobar location compared with histological GBMs, resulting in less aggressive resection. Survival was significantly longer in molecular GBM, which was attributed to the longer OS in histological grade 2 molecular GBMs with isolated TERTp mutation.

Impact: Discordant clinicopathologic, imaging, and surgical features suggest molecular GBMs may not be equivalent to early histological GBMs. Histological grade 2 molecular GBMs with isolated TERTp mutation may not be sufficient to assume an aggressive clinical behavior similar to histological GBM.

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Keywords

molecular