Keywords: Tumors (Pre-Treatment), Brain, glioma
Motivation: Accurate preoperative noninvasive diagnosis and classification of diffuse gliomas have a significant impact on clinical management and are of significant prognostic importance.
Goal(s): To investigate the diagnostic efficacy and clinical value of preoperative DCE-MRI in predicting genotype and prognosis of glioma.
Approach: Adult diffuse gliomas were enrolled. Univariate and multivariate logistic or cox regression analysis are performed for diagnosing glioma gene and prognosis.
Results: Preoperative DCE-MRI exhibits favorable diagnostic capabilities in identification of IDH mutation status with AUC value of 0.77, 1p19q codeletion with AUC value of 0.71, and CDKN2A/B homozygous deletion with AUC value of 0.93, and assessment of glioma prognosis.
Impact: This study highlighted potential clinical application of DCE-MRI by demonstrating the robust diagnostic performance of DCE-derived parameters. These parameters exhibited not only excellent diagnostic accuracy in identifying functional biomarkers such as IDH, 1p19q and CDKN2A/B, but also in predicting prognosis.
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