Abstract #3590

Non-Stationarity of Resting-State Connectivity in Patients with Brain Tumors in the Awake and Anesthetized State

Jing Zhang¹, Luca Vizioli², Curtis Tatsuoka³, Essa Yacoub², Clark Chen⁴, and Stefan Posse^5,6

¹Dept. of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, United States, ²Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN, United States, ³Dept. of Medicine, Div. of Hematology/Oncology, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Dept. of Neurosurgery, University of Minnesota, Minneapolis, MN, United States, ⁵Univ. of New Mexico, Dept. of Neurology, Albuquerque, NM, United States, ⁶Physics and Astronomy, University of New Mexico, Albuquerque, NM, United States

Synopsis

Keywords: Tumors (Pre-Treatment), fMRI (resting state), connectivity dynamics, temporal autocorrelation, Intra-operative

Motivation: Map temporal fluctuations of functional connectivity (FC) in anesthetized brain tumor patients.

Goal(s): Map static FC (sFC), dynamic inter-region FC (dFC), and test-retest reliability between awake and anesthetized states in patients undergoing resection of brain tumors.

Approach: A sliding-window xDF method was developed to estimate variance of the correlation in spatial-temporal resolution resting-state fMRI, considering nonstationary autocorrelation and cross-correlation.

Results: The largest decrease in sFC during anesthesia was observed across, rather than within, networks. The sliding-window xDF increased sensitivity compared to the static model. Test-retest reliability between cortical areas was higher during anesthesia versus awake state, in contrast to subcortical and cortical-subcortical dFC.

Impact: These results demonstrate the feasibility of performing resting-state functional connectivity studies in intraoperative settings with high spatial-temporal resolution. The higher test-retest reliability within cortical areas during anesthesia versus awake state informs the design of minimum duration intra-operative resting-state fMRI protocols.

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