Keywords: Multi-Contrast, Modelling, Fixation, Postmortem whole human brain, Hydration
Motivation: Relaxation rates in the in-vivo human brain are strongly different to their counterparts in formalin-fixed postmortem tissue.
Goal(s): To model the changes of the relaxation rate parameters for different tissue stages from in-vivo to ex-vivo: unfixed, during fixation and during hydration.
Approach: The multi-parameter mapping (MPM) protocol was used to measure the changes of five whole-human brains across the aforementioned tissue stages, and different saturation models were tested to describe relaxation parameter changes during fixation.
Results: The MPM parameters varied strongly per tissue stage, and a mathematical description of the change of the MPM during fixation was found.
Impact: We characterised the MPM parameters during the fixation and hydration process across the entire brain and propose a mathematical model to describe the changes. This information could facilitate translating microstructure-mapping methods from fixed ex-vivo tissue samples to in-vivo application
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