Abstract #3685

Added Value of Electrical Conductivity Information to Apparent Diffusion Coefficient in Distinguishing Thoracic Lesions

Jincheng Wang¹, Ulrich Katscher², Eiki Kikuchi³, Maho Kitagawa¹, Yasuka Kikuchi⁴, Yuki Yoshino⁴, and Khin Khin Tha^1,5

¹Laboratory for Biomarker Imaging Science, Hokkaido University Graduate School of Medical Science and Engineering, Sapporo, Japan, ²Philips Research Laboratories, Hamburg, Germany, ³Department of Respiratory Medicine, Hokkaido University Faculty of Medicine, Sapporo, Japan, ⁴Department of Diagnostic Imaging, Hokkaido University Faculty of Medicine, Sapporo, Japan, ⁵Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Sapporo, Japan

Synopsis

Keywords: Electromagnetic Tissue Properties, Electromagnetic Tissue Properties

Motivation: The electrical conductivity (σ) has been proven as helpful for glioma and breast cancer characterization. Our prior study also suggests its potential utility in distinguishing benign and malignant thoracic lesions.

Goal(s): This study aimed to evaluate the added value of σ to thoracic lesion diagnosis by apparent diffusion coefficient (ADC).

Approach: In this prospective study, we used radiomics analysis to evaluate the prediction value of ADC and σ. The diagnostic performance of selected ADC, σ, and composite indices were compared.

Results: 7 independent features were identified in 21 lesions. Half of the top 4 features were from σ. All indices achieved excellent performance.

Impact: The results of this preliminary study highlight the potential usefulness of noninvasive electrical conductivity (σ) measurement in the characterization of thoracic lesions.

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