Abstract #3689

Relationship between QSM, R2*, and a polygenic risk score for unusual and psychotic experiences

Marisleydis Garcia-Saborit^1,2,3,4, Eduardo Perez-Palma⁵, Camilo Villaman⁶, Gabriela Repetto⁷, Carlos Milovic⁸, Nicolás Crossley^3,4,9, and Cristian Tejos^1,3,4

¹Department of Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile, ²Biomedical Engineering, Faculty of Engineering, Universidad de Santiago de Chile, Santiago de Chile, Chile, ³Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile, ⁴Millennium Institute for Intelligent Healthcare Engineering, Santiago de Chile, Chile, ⁵Center for Genetics and Genomics, Clinica Alemana Universidad del Desarrollo, Santiago de Chile, Chile, ⁶Center for Genomics and Bioinformatics, Universidad Mayor, Santiago de Chile, Chile, ⁷Rare Diseases Program, School of Medicine, Santiago de Chile, Chile, ⁸School of Electrical Engineering, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile, ⁹Department of Psychiatry, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile

Synopsis

Keywords: Electromagnetic Tissue Properties, Brain

Motivation: Psychosis has been studied from different perspectives, including genetic factors and dopamine dysfunction. However, those perspectives have been studied independently.

Goal(s): To investigate the relationship between genetic factors (i.e., Polygenic Risk Score, PSR) and magnetic tissue properties associated with dopamine (QSM, R2*) in a cohort of individuals with psychotic experiences.

Approach: Analyze the potential correlations among QSM, R2* and PRS scores using linear mixed models in a cohort of patients and controls obtained from the UK Biobank.

Results: We identified significant predictors for QSM and R2* values with PRS, revealing differences in specific brain regions associated with dopamine pathways.

Impact: The changes found in the brain regions associated with dopamine pathways provide further evidence to support that psychosis may be related to a dopamine dysfunction, and those changes may also be related to genetic factors.

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