Keywords: Quantitative Imaging, Quantitative Imaging, Major depressive disorder; synthetic MRI; myelin
Motivation: Major depressive disorder is a common mental illness with biological processes, such as myelin alterations, that are not yet fully understood.
Goal(s): This study aims to explore myelin abnormalities in MDD patients utilizing Synthetic MRI (SyMRI) technique.
Approach: Myelin content measured by SyMRI was compared between 32 MDD patients and 51 healthy controls, and the study further investigated the relationship between myelin alterations and the depressive symptoms.
Results: Several white matter regions exhibited a significant decrease in myelin content in individuals with MDD, and a correlation was found between the depressive symptoms and these myelin deficits.
Impact: The present study highlights the potential of Synthetic MRI technique as a valuable tool for measuring myelin content, which could play a crucial role in understanding the underlying neurobiological mechanisms of Major Depressive Disorder.
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